Anh Van Thi Pham1,#, Anh Quang Luong2,3,#, Dung Kim Thi Dao4, Vy Nhat Dao Nguyen4, Tam
Cong Nguyen4, Thoa Thi Dao4, Long Hai Luu5,6, Lan Hai Luu5,6, Gioi Huy Dong6, Huong Thu Thi
Bui6, Tung Thanh Tran1, Duong Thuy Dau1, Hai Van Nguyen7, Minh Hai Luu5,# and Loan Thanh
Thi Nguyen1,*
1Department of Pharmacology, Hanoi Medical University, Hanoi 10000, Vietnam
2Department of Pharmacy and Medical Equipment, National Burn Hospital, Hanoi 10000, Vietnam
3Vietnam Military Medical University, Hanoi 10000, Vietnam
4DKD International Production Joint Stock Company, Ho Chi Minh 70000, Vietnam
5Nhat Hai New Technology Joint Stock Company, Hanoi 10000, Vietnam
6Vietnam National University of Agriculture, Hanoi, Vietnam
7Hanoi University of Pharmacy, Hanoi, Vietnam

Abstract:
Background: Burn injuries and skin ulcers are important health problems resulting in physical and psychological
scars and chronic disabilities. This study investigated the wound-healing effects of liposomal nanocurcumin and PL
pro nanocurcumin on thermal burns in rats and doxorubicin-induced skin ulcers in mice and their systemic toxicity.
Methods: Having subjected to a cylindrical hot steel rod onto the dorsum, burned lesions were covered topically with
silver sulfadiazine/liposomal nanocurcumin/PL pro nanocurcumin twice a day for 21 days. Besides, the other skin
lesions which were induced by a single intradermal injection of doxorubicin on the dorsal region were topically
administered with dimethyl sulfoxide/liposomal nanocurcumin/PL pro nanocurcumin twice a day for 21 days.
Results: The results indicated that liposomal nanocurcumin and PL pro nanocurcumin significantly reduced the
wound size, increased the hydroxyproline content in animals’ skin, and improved the histopathological structure of
the affected tissues. Specifically, liposomal nanocurcumin demonstrated better healing results than PL pro
nanocurcumin on thermal burns. Furthermore, topical administration of liposomal and PL pro nanocurcumin was
deemed not to exert any systemic toxicity to the wounded animals by not influencing considerably the hematological
parameters and renal and hepatic functions and altering the histology of the liver and kidney. Additionally, liposomal
nanocurcumin and PL pro nanocurcumin with average sizes of 206 nm and 344 nm were well-dispersed in water,
accentuating that the disadvantages of limited water solubility have been overcome.
Conclusion: Thus, liposomal nanocurcumin and PL pro nanocurcumin exerted effective effects on burned wounds
and skin ulcers whilst triggering no systemic toxicity in wounded animals.
Keywords: Liposomal nanocurcumin, PL pro nanocurcumin, Burn, Skin ulcer, Healing, Wounded animals

1. INTRODUCTION
Curcumin has perennially been referred to as a
bioactive, important compound found in nature. To be
specific, this substance is isolated from Curcuma longa L.,
which belongs to the Zingiberaceae species with a
scientific name of (1e,6e)-1,7-bis(4-hydroxy-3’-methoxy
phenyl)-1,6-heptadiene-3,5-dione [1, 2]. For years,
curcumin has been profoundly embedded in the sociocultural lifestyle of different peoples, especially Asians. It
is not only considered a nature-based colorant, flavouring
agent, and food preservative in many local cuisines but is
also utilized for the sake of curing many illnesses.
Regarding the pharmacological properties, many
beneficial biological features of curcumin have been
identified, such as anti-oxidant, anti-inflammatory, antimicrobial, anti-mutagenic, anti-tumoral, anti-angiogenesis activities, and wound healing effects [3-10].
Besides the evidence for the diversity of bioactivities of
curcumin, this substance barely exhibits any toxicity at
high doses when used for clinical treatment purposes
[11-16]. Therefore, this statement does pave the way for
curcumin to be popularly studied in various research
studies relating to the dysregulation of many human
organs. In particular, when it comes to some skin
disorders and damages with many free radicals emitted,
curcumin improves the skin with its capability to eradicate
reactive oxygen species and attenuates local inflammation
by inhibiting the nuclear receptor NF-κB [17].
Furthermore, treating skin disorders with curcumin does
help to shorten the wound healing time, enhance the
deposition of collagen, and also increase the density of
fibroblasts and vasculatures, thus reinforcing the healing
of the affected tissue with different levels of severity
[18-20].
Notwithstanding those mentioned beneficial features,
curcumin does exhibit many limitations, including poor
water solubility and physicochemical instability, less
bioactive absorption, rapid metabolization, and low
penetration and targeting efficacy [21-24]. Meanwhile,
nanoformulation has been testified regarding the potential
of targeted delivery to the tissue of interest that leads to
enhanced bioavailability and bioactivity and better drug
carriage [25-28]. With the intention of taking advantage of
this compound and simultaneously solving its drawbacks,
the advent of nanocurcumin has shown to be prominent.
There are currently several methods to encapsulate
curcumin molecules at the nanoscale, and each uses a
different but suitable nanocarrier [29].
Burn injuries and skin ulcers are still considered
important health problems affecting both genders and all
age groups, resulting in physical and psychological scars
and leading to chronic disabilities [30-33]. To date,
research on burns has generated sustained interest over
the past few decades. In current burn therapy, silver
sulfadiazine has been presented as the gold standard in
topical second-degree burn treatment because of its
antibacterial activities [34, 35]. However, the effect of
silver sulfadiazine stems from the toxicity towards
keratinocytes and fibroblasts, hence decelerating the

1. INTRODUCTION
Curcumin has perennially been referred to as a
bioactive, important compound found in nature. To be
specific, this substance is isolated from Curcuma longa L.,
which belongs to the Zingiberaceae species with a
scientific name of (1e,6e)-1,7-bis(4-hydroxy-3’-methoxy
phenyl)-1,6-heptadiene-3,5-dione [1, 2]. For years,
curcumin has been profoundly embedded in the sociocultural lifestyle of different peoples, especially Asians. It
is not only considered a nature-based colorant, flavouring
agent, and food preservative in many local cuisines but is
also utilized for the sake of curing many illnesses.
Regarding the pharmacological properties, many
beneficial biological features of curcumin have been
identified, such as anti-oxidant, anti-inflammatory, antimicrobial, anti-mutagenic, anti-tumoral, anti-angiogenesis activities, and wound healing effects [3-10].
Besides the evidence for the diversity of bioactivities of
curcumin, this substance barely exhibits any toxicity at
high doses when used for clinical treatment purposes
[11-16]. Therefore, this statement does pave the way for
curcumin to be popularly studied in various research
studies relating to the dysregulation of many human
organs. In particular, when it comes to some skin
disorders and damages with many free radicals emitted,
curcumin improves the skin with its capability to eradicate
reactive oxygen species and attenuates local inflammation
by inhibiting the nuclear receptor NF-κB [17].
Furthermore, treating skin disorders with curcumin does
help to shorten the wound healing time, enhance the
deposition of collagen, and also increase the density of
fibroblasts and vasculatures, thus reinforcing the healing
of the affected tissue with different levels of severity
[18-20].
Notwithstanding those mentioned beneficial features,
curcumin does exhibit many limitations, including poor
water solubility and physicochemical instability, less
bioactive absorption, rapid metabolization, and low
penetration and targeting efficacy [21-24]. Meanwhile,
nanoformulation has been testified regarding the potential
of targeted delivery to the tissue of interest that leads to
enhanced bioavailability and bioactivity and better drug
carriage [25-28]. With the intention of taking advantage of
this compound and simultaneously solving its drawbacks,
the advent of nanocurcumin has shown to be prominent.
There are currently several methods to encapsulate
curcumin molecules at the nanoscale, and each uses a
different but suitable nanocarrier [29].
Burn injuries and skin ulcers are still considered
important health problems affecting both genders and all
age groups, resulting in physical and psychological scars
and leading to chronic disabilities [30-33]. To date,
research on burns has generated sustained interest over
the past few decades. In current burn therapy, silver
sulfadiazine has been presented as the gold standard in
topical second-degree burn treatment because of its
antibacterial activities [34, 35]. However, the effect of
silver sulfadiazine stems from the toxicity towards
keratinocytes and fibroblasts, hence decelerating the

wound healing process and probably triggering serious
cytotoxic effects on the host cells. Furthermore, there are
quite a number of articles to be reviewed on some
emerging sliver-sulfadiazine-resistant organisms [36-38].
Additionally, in the treatment of skin ulceration, dimethyl
sulfoxide (DMSO) is perennially one of the most proposed
remedies since it can easily infiltrate into the affected area
and scavenge free radicals, which is an important etiology
of serious tissue damage [39]. However, for the time
being, the accessibility of DMSO and other effective
agents for skin ulcers is still restricted. Therefore, seeking
a safer and more effective treatment approach towards
skin lesions has been critically demanded in healthcare
practice, particularly those caused by thermal or chemical
triggers.
The beneficial effects and potentials of curcumin in
different nano-based dosage forms, including liposomal
nanocurcumin and PL pro nanocurcumin, with the
assessment in terms of healing effects in both burned and
ulcerated skin lesions, as well as the systemic toxicity in
the experimental model remain unclear. In the present
study, we investigated the wound-healing effect of
liposomal nanocurcumin and PL pro nanocurcumin on
thermal burns in rats and doxorubicin-induced skin ulcers
in mice and their systemic toxicity in ulcerated
experimental animals.
2. MATERIALS AND METHODS
2.1. Preparation of Liposomal Nanocurcumin and PL
Pro Nanocurcumin Formula
2.1.1. Liposomal Nanocurcumin
Firstly, nanocurcumin was created. The dispersed
phase by dissolving curcumin in ethanol was prepared
with a volume ratio of 4/5. Then, a carrier mixture
consisting of polyethylene glycol (PEG) and ethylene glycol
by dispersing polyethylene glycol and ethylene glycol well
in water was made with a ratio of approximately 1.5/6/2
for polyethylene glycol/ethylene glycol /water, under
ultrasonic vibration for about 2 hours at room
temperature. A homogeneous mixture was made by mixing
the dispersed phase/liquid in the previous step, the carrier
mixture, and the emulsifier lecithin such that the ratio of
curcumin/PEG/lecithin in this homogenizer was 1.6/1.5/2
using an emulsifier. Nano-emulsions of curcumin were
created by allowing the mixture to homogenize overnight
and then centrifugated at room temperature at 5000 rpm
for about 10 minutes, which was repeated six times. After
obtaining curcumin nano-emulsions, nano-curcumin and
phospholipids were weighed and prepared according to
the respective ratio of 1/1. Liposomal nanocurcumin was
obtained by putting the prepared mixture into the
emulsifier and heating it at 120oC within 4 hours.
2.1.2. PL Pro Nanocurcumin
Nano curcumin was prepared using the method
described above. PL pro included 18% phosphatidylcholine, 21% cholesterol, 27% lecithin, 9.5% folic acid,
15% nano curcumin, 3% tocopherol, 3% xanthan gum, 3%

wound healing process and probably triggering serious
cytotoxic effects on the host cells. Furthermore, there are
quite a number of articles to be reviewed on some
emerging sliver-sulfadiazine-resistant organisms [36-38].
Additionally, in the treatment of skin ulceration, dimethyl
sulfoxide (DMSO) is perennially one of the most proposed
remedies since it can easily infiltrate into the affected area
and scavenge free radicals, which is an important etiology
of serious tissue damage [39]. However, for the time
being, the accessibility of DMSO and other effective
agents for skin ulcers is still restricted. Therefore, seeking
a safer and more effective treatment approach towards
skin lesions has been critically demanded in healthcare
practice, particularly those caused by thermal or chemical
triggers.
The beneficial effects and potentials of curcumin in
different nano-based dosage forms, including liposomal
nanocurcumin and PL pro nanocurcumin, with the
assessment in terms of healing effects in both burned and
ulcerated skin lesions, as well as the systemic toxicity in
the experimental model remain unclear. In the present
study, we investigated the wound-healing effect of
liposomal nanocurcumin and PL pro nanocurcumin on
thermal burns in rats and doxorubicin-induced skin ulcers
in mice and their systemic toxicity in ulcerated
experimental animals.
2. MATERIALS AND METHODS
2.1. Preparation of Liposomal Nanocurcumin and PL
Pro Nanocurcumin Formula
2.1.1. Liposomal Nanocurcumin
Firstly, nanocurcumin was created. The dispersed
phase by dissolving curcumin in ethanol was prepared
with a volume ratio of 4/5. Then, a carrier mixture
consisting of polyethylene glycol (PEG) and ethylene glycol
by dispersing polyethylene glycol and ethylene glycol well
in water was made with a ratio of approximately 1.5/6/2
for polyethylene glycol/ethylene glycol /water, under
ultrasonic vibration for about 2 hours at room
temperature. A homogeneous mixture was made by mixing
the dispersed phase/liquid in the previous step, the carrier
mixture, and the emulsifier lecithin such that the ratio of
curcumin/PEG/lecithin in this homogenizer was 1.6/1.5/2
using an emulsifier. Nano-emulsions of curcumin were
created by allowing the mixture to homogenize overnight
and then centrifugated at room temperature at 5000 rpm
for about 10 minutes, which was repeated six times. After
obtaining curcumin nano-emulsions, nano-curcumin and
phospholipids were weighed and prepared according to
the respective ratio of 1/1. Liposomal nanocurcumin was
obtained by putting the prepared mixture into the
emulsifier and heating it at 120oC within 4 hours.
2.1.2. PL Pro Nanocurcumin
Nano curcumin was prepared using the method
described above. PL pro included 18% phosphatidylcholine, 21% cholesterol, 27% lecithin, 9.5% folic acid,
15% nano curcumin, 3% tocopherol, 3% xanthan gum, 3%

Camellia sinensis extract, and 0.5% Aloe vera extract, then
nano curcumin and PL pro were mixed according to the
corresponding volume ratio of 1/1 in the emulsifier. After
two hours, PL pro nanocurcumin was obtained.
2.2. Particle Size
Liposomal nanocurcumin and PL pro nanocurcumin
samples were tested to determine particle size. This
process was carried out utilising Malvern Mastersizer
(Malvern Instruments Ltd., United Kingdom). The
measurement was carried out by dissolving particles in
water before measuring. The system temperature was
kept at about 25°C. Hence, the solution was checked in
terms of limitations regarding solubility.
The stability of liposomal nanocurcumin and PL pro
nanocurcumin was determined through an accelerated
aging test. This test simulates the aging process over time
by subjecting the samples to high temperatures to
artificially expedite the aging process. The accelerated
aging process was conducted using an incubator (Daihan
Scientific, South Korea), maintaining a constant
temperature of 40°C for six months.
2.3. Experimental Animals
Male and female Wistar rats weighing 180 ± 20g and
seven-week-old male and female Swiss albino mice were
obtained from the National Institute of Hygiene and
Epidemiology, Hanoi, Vietnam. All experimental protocols
were in accordance with the National Guideline (reference
number: 141/QD-K2DT). This study was approved by the
Scientific Board Committee of Hanoi Medical University,
Vietnam (ref number: IRB00003121). All animals were
housed in a controlled environment (25 ± 1ºC under 65 ±
5% humidity and a 12-hour light and dark cycle) with ad
libitum to access the standard rodent diet and water. The
animals were given for at least one week to acclimate
before starting the experiments.
2.4. Healing Effect of Topical Administration of
Liposomal Nanocurcumin and PL Pro Nanocurcumin
Creams
2.4.1. Thermal Burn in Rats
We followed the previously reported model of thermal
burns on rats. A total of 50 rats were randomly divided
into five groups of ten animals. The rats were anesthetized
with a single intraperitoneal injection of 250 mg/kg
chloralhydrate (Sigma Aldrich, St. Louis, MO, USA). As
preparation, they were shaven at the dorsum with an
electric shaver and later sterilized with 70% alcohol. All
animals, except the normal control group, were subjected
to thermal burns on the back of each rat by using a
standard burning technique [40]. Burn wounds were
formed by applying a 200-gram cylindrical stainless-steel
rod (2.5 cm diameter) without any pressure, which was
pre-heated to 100°C in boiling water with the thermal
equilibrium confirmed by a monitoring thermometer, onto
the shaven skin for 35 seconds. All animals were
resuscitated immediately with Lactated Ringer’s solution
(2 ml/100 g body weight) intraperitoneally. Following the
burning, each animal was placed in a separate cage, and
the affected areas were covered with 0.3 g silver
sulfadiazine, liposomal nanocurcumin, or PL pro
nanocurcumin twice a day for 21 days. The vehicle-treated
burned rats topically received sterile distilled water (Fig.
1A).
2.4.2. Doxorubicin-induced Skin Ulcer in Mice
Fifty mice were randomly divided into five groups of
ten animals. Mice were anesthetized with an
intraperitoneal injection of 350 mg/kg chloralhydrate.
After anesthesia, the dorsal regions were shaven with an
electric shaver and sterilized with 70% alcohol. All
animals, except the normal control group, were induced
skin ulcers by a single intradermal injection of 0.2 ml
doxorubicin 1 mg/0.5 ml (Doxorubicin Ebewe, Austria)
[41]. Then, each animal was placed in a separate cage.
Seven days after the injection of doxorubicin, the vehicletreated ulcerated mice topically received sterile distilled
water. The other ulcerated mice were topically applied 0.3
ml DMSO (Sigma Aldrich, St. Louis, MO, USA) twice a day,
0.3 g liposomal nanocurcumin or PL pro nanocurcumin
twice a day for 21 days (Fig. 1B).
2.4.3. Measurement of the Wound Size
Wound sizes of animals in two experiments were
measured using a digital camera with one camera lens and
from a constant focal distance. The area of the wound was
measured in a blind manner using ImageJ basics software
ver 1.38, which was recognized as software for measuring
the area in medical experimental research by the World
Health Organization.
2.4.4. Determination of the Hydroxyproline Content
At the end of two experiments, mice and rats were
anesthetized with chloralhydrate, and skin samples were
collected from each animal. The concentration of
hydroxyproline in the skin was evaluated according to the
Stegemann H. and Stalder K method [42]. Briefly, 20 to 30
mg of skin tissues were put into hydrolytic tubes with 2
mL HCl 6N. These tubes were incubated at 115°C. After
24 hours, the hydrolyzed fluid was collected into the test
tubes. Each test tube included 0.2 mL hydrolyzed fluid of
samples, 1.8 mL distilled water, and 1 mL chloramine T.
These test tubes were shaken and kept at room
temperature for 20 minutes. Then, 2 mL pechloric acid 4M
was added, shaken well, and let stand for 5 minutes at
room temperature. 4-Dimethylaminobenzaldehyde 10%
was added, shaken well, and kept in a bain-marie at 60oC
for 15 minutes. These tubes were cooled down to room
temperature and measured the light of 560 nm wavelength
absorption (Shimadzu, Japan).
2.4.5. Histopathological Evaluation
The ulcerated skin tissue samples were collected for
histopathological examinations. Histopathological evaluation was carried out randomly in 30% of each group.
These tissue samples were fixed in 10% neutral-buffered

Fig. (1). Experimental protocols. (A) Experimental protocol for evaluating the effects of topical administration of liposomal nanocurcumin
and PL pro nanocurcumin creams on thermal burns in rats. (B) Experimental protocol for evaluating the effects of topical administration
of liposomal nanocurcumin and PL pro nanocurcumin creams on doxorubicin-induced skin necrosis in mice

formalin solution before they were embedded in paraffin
wax and cut into 5 μm-thick sections to be stained with
hematoxylin and eosin (H&E). The pathologist who
examined the slides was blind to group allocation. Under
histopathological examinations, inflammation, epithelization, neovascularization, and necrosis were evaluated.
2.5. Evaluation of systemic toxicity of topical
administration of liposomal nanocurcumin and PL
pro nanocurcumin creams in wounded animals
Blood samples were collected from each animal. The
systemic effects were quantified through general
conditions, including body weight changes in mice.
Moreover, the hematopoietic function was evaluated
through red blood cell count, hemoglobin, hematocrit,
total white blood cells, and platelet count. The liver
damage was examined through aspartate aminotransferase level (AST) and alanine aminotransferase level
(ALT), and the liver function was measured through total
bilirubin, albumin, and total cholesterol. Furthermore,
kidney function was examined through creatinine level.
Follow-up parameters were checked at the time points
before applying the products after 10 and 21 days in the
thermal burn model in rats (Fig. 1A). In the doxorubicininduced skin ulcer model in mice, blood samples were
obtained after 21 days of treatment (Fig. 1B).
At the end of the experiments, animals were
euthanized after blood collection, and the internal organs
(heart, liver, spleen, kidney, and lung) were removed and
observed for any gross lesions. The liver and kidneys of
30% of the animals in each group were preserved in a 10%
buffered formaldehyde solution for histopathological
studies using hematoxylin and eosin (H&E) staining by a
researcher blinded to the study.
2.6. Data Analysis
Sigmaplot 12.0 (SYSTA Software Inc, Richmond, CA,
USA) was used for statistical analysis. Obtained data were
expressed as the mean ± S.D and compared with either
one-way-ANOVA, followed by the post hoc StudentNewman-Keuls test for multiple comparisons or Fisher’s
Exact test for two proportions. Statistically significant
differences were considered when the p-value was less
than 0.05.
3. RESULTS
3.1. Particle Size
Liposomal nanocurcumin and PL pro nanocurcumin
with average sizes of 206 and 344 nm were well-dispersed
in water, indicating that the disadvantages of limited
water solubility have been overcome. Furthermore, the
results of the accelerated aging study revealed that after
six months of accelerated aging at 40°C, both liposomal
nanocurcumin and PL pro nanocurcumin remained stable
in particle size (Fig. S1).

3.2. Healing Effects of Liposomal Nanocurcumin and
PL Pro Nanocurcumin on Thermal Burns in Rats
3.2.1. Effect on the Wounded Area
As shown in Fig. (2), after 7 days of treatment, there
was no difference in burned area between groups. After 14
days of administration, silver sulfadiazine, liposomal
nanocurcumin, and PL pro nanocurcumin markedly
reduced the wounded area compared to the vehicletreated model group (vehicle-treated burned group vs.
silver sulfadiazine-treated burned group, p=0.003; vehicletreated burned group vs. liposomal nanocurcumin-treated
group, p<0.001; vehicle-treated burned group vs. PL pro
nanocurcumin-treated group, p=0.003). The burned area
of liposomal nanocurcumin-treated rats significantly
decreased compared with the PL pro nanocurcumintreated rats (p=0.006).
After 21 days of treatment, the burn lesions of vehicletreated rats were not completely healed. The rate of burn
wound healing in the silver sulfadiazine- and liposomal
nanocurcumin-treated groups was 50%, with a statistically
significant difference compared to the vehicle-treated
group (p=0,033; Fisher’s exact test). PL pro nanocurcumin-treated rats had a wound healing rate of 20%.
There was no markedly significant difference in the rate of
wound healing between the vehicle-treated group and the
PL pro nanocurcumin-treated group (p>0.05).
3.2.2. Effect on Hydroxyproline Content
As shown in Fig. (3), the content of hydroxyproline in
the rat skin sample of the vehicle-treated group was
significantly lower than the normal control group
(p<0.001). Compared with the vehicle-treated model
group, treatment of silver sulfadiazine, liposomal
nanocurcumin, and PL pro nanocurcumin was found to
increase the level of hydroxyproline in the skin tissue
(vehicle-treated burned group vs. silver sulfadiazinetreated burned group, p=0.002; vehicle-treated burned
group vs. liposomal nanocurcumin-treated group,
p<0.001; vehicle-treated burned group vs. PL pro
nanocurcumin-treated group, p<0.001).

3.3. Evaluation of Systemic Toxicity of Topical
Administration of Liposomal Nanocurcumin and PL

between liposomal nanocurcumin and PL pro
nanocurcumin-treated rats and the normal control group

Table 1. Effect of liposomal nanocurcumin and PL pro nanocurcumin on hematopoietic function in burned rats.

After 21 days of administration, the rate of wound
healing in vehicle-treated mice was 10%. The rate of wound
healing in the silver sulfadiazine- and the liposomal
nanocurcumin-treated group was 70% and 80%,
respectively (p=0.02 and p=0.005 compared to the vehicletreated group; Fisher’s Exact test). PL pro nanocurcumintreated mice had a wound healing rate of 60%. There was
no noticeably significant difference in the rate of wound
healing between the vehicle-treated group and the PL pro
nanocurcumin-treated group (p=0.057).

3.4.2. Effect on Hydroxyproline Content
The hydroxyproline content is presented in Fig. (7). The
hydroxyproline level in skin tissues of the vehicle-treated
group was significantly lower than the normal control group
(p<0.001). Compared with the vehicle-treated model group,
treatment of DMSO, liposomal nanocurcumin, and PL Pro
nanocurcumin significantly increased the hydroxyproline
content in the skin tissue. In addition, there were no
significant differences in the effects of liposomal
nanocurcumin and PL pro nanocurcumin on the
concentration of hydroxyproline in skin tissues (p>0.05).

3.4.3. Histopathological Examination
The skin biopsy of the normal control mice was normal,
with the proper stratum epidermis with keratinization,
clear basal lamina, skin-dependent components in the
dermis layer, loose connective tissue, and small blood
vessels. In the vehicle-treated ulcerated mice, the skin
tissue showed a large necrosis area, and the surface was
covered with necrotic substances, erythrocytes, fibrin,
many inflammatory cells, neutrophils, and macrophages.
On the 21st day, DMSO, liposomal nanocurcumin, and PL
pro nanocurcumin improved the histopathological
structure of skin tissues, which demonstrated the slight
growth of dermal papillae and epidermal ridges.
3.5. Evaluation of Systemic Toxicity of Topical
Administration of Liposomal Nanocurcumin and PL
Pro Nanocurcumin in Ulcerated Mice
During the experimental period, there was an increase
in body weight in each group of animals. No significant
differences were seen as compared to that of the control
group. None of the animals in all treated groups showed
any macroscopic or gross pathological changes when
compared to the control group. No gross lesions or changes
in size were observed when evaluating all experimental rats
to a full gross necropsy, which examined the hearts, livers,
lungs, kidneys, and abdominal cavities.
3.5.1. Effect on Hematopoietic Function
As mentioned in Table 3, there were no significant
differences in red blood cell count, hematocrit, hemoglobin
level, total white blood cell, and platelet count between
liposomal nanocurcumin and PL pro nanocurcumin-treated
groups and normal control group (p>0.05).
3.5.2. Effect on Liver Damage, Liver Function, and
Kidney Function
Fig. (8) demonstrates that liposomal nanocurcumin and
PL pro nanocurcumin did not cause any statistical
difference in AST, ALT level, and creatinine levels when
comparing the treated groups to the normal control group
(p>0.05). The effects of liposomal nanocurcumin and PL pro
nanocurcumin on the total bilirubin, albumin, and total
cholesterol of the normal control group and treated groups
are presented in Table 4. No statistical difference was
observed between groups (p>0.05).
Additionally, there were no significant differences in
histopathological examinations of livers and kidneys
between liposomal nanocurcumin and PL pro nanocurcumin-treated ulcerated and normal control mice (Fig.
S2B).

4. DISCUSSION
In this study, we not only evaluated the effect of
topical administration of liposomal nanocurcumin and PL
pro nanocurcumin on two different models of skin lesions,
which were induced, respectively, by heat and doxorubicin
but also detected any systemic toxicity of liposomal and PL
pro nanocurcumin via the ulcers in the experimental
animals. Our results showed that liposomal nanocurcumin
and PL pro nanocurcumin significantly reduced the size of
the wounded area, increased the hydroxyproline level in

skin tissues, and improved the histopathological structure
of skin tissues. Liposomal nanocurcumin showed better
effects than PL pro nanocurcumin on thermal burns in
rats. Additionally, topical administration of liposomal
nanocurcumin and PL pro nanocurcumin did not cause
systemic toxicity. Thus, liposomal nanocurcumin and PL
pro nanocurcumin have been shown to accelerate the
wound healing process without systemic toxicity in
experimental rat models.

Thermal burn injuries and skin ulcers are still
considered major health problems, resulting in physical
and psychological scars and disabilities [30]. Depending
on the lesion severity, wound healing is one of the most
complex processes, which involves several phases of
coagulation, inflammation, growth, re-epithelialization,
and remodeling [43, 44]. Research on burns has generated
sustained interest over the past few decades. However,
drugs for treating burns and skin ulcers are still limited
[36]. For the treatment of burns, silver sulfadiazine is
considered the gold standard in the topical treatment of
second-degree burns because of its antibacterial
properties. However, silver sulfadiazine is associated with
toxicity to keratinocytes and fibroblasts. So, this drug
delays the wound healing process and has some serious
cytotoxic effects on the host cells. Moreover, several
bacteria are resistant to silver sulfadiazine [36].
Additionally, for the treatment of skin ulcers, dimethyl

sulfoxide (DMSO) is a perennially proposed remedy since
it can easily infiltrate into the affected area and scavenge
free radicals [39]. However, currently, the pharmaceutical
form of DMSO is limited. Moreover, the accessibility of
DMSO in particular and other effective agents for skin
ulcers is still restricted. Considering this, there is an
emerging demand for a safer and more effective approach
to be applied in the treatment of wounds.
Curcumin possesses a powerful wound-healing effect
for the treatment of various skin disorders and damages
[5, 45-47]. In particular, curcumin attenuates the
inflammatory response and hastens wound healing by
increasing cellular proliferation and improving collagen
deposition in the wound tissues, as well as promoting
angiogenesis in chronic wounds [48-50]. Thus, curcumin
reinforces the healing of the affected tissue with different
levels of severity. Effect on inflammation, fibroblast
proliferation, granulation tissue formation, and collagen
deposition are mentioned mechanisms of the healing
potential of curcumin [51-53]. However, curcumin exhibits
several limitations in wound healing treatment, including
poor water solubility and physicochemical instability [21].
As a solution, nanoformulations should be applied in order
to deliver substance to the targets more accurately [20].
Specifically, liposomes with nano-sized phospholipid
bilayered vesicles were utilized for transport with a variety
of drugs, including wound healing agents. These are not
difficult to prepare and are highly biocompatible in nature.
This approach of nanoformulation has shown promising
results in the improvement of aqueous solubility of
curcumin and the development of a sustained and
prolonged drug-release system, thus enhancing wound
healing and closure [54]. In the present study, thermal
burn wounds in rats and doxorubicin-induced skin ulcers
in mice were used to evaluate the healing effect of topical
administration of liposomal nanocurcumin and PL pro
nanocurcumin. Liposomal nanocurcumin and PL pro
nanocurcumin significantly reduced the size of the
wounded area, increased the hydroxyproline content in
skin tissues, and improved the histopathological structure
of skin tissues. In addition to assessing the criteria for the
damaged area of skin ulcer, we also evaluated the
hydroxyproline level. According to the literature, collagen
plays a pivotal role in wound healing. Hydroxyproline is a
major component of the protein collagen, as it is a
principal component of connective tissues produced by
fibroblasts. It assists the wound in gaining tensile strength
during wound repair, hence serving as a structural
framework, strength, and milieu for the regenerating
tissue [55-68]. We determined collagen synthesis
indirectly by hydroxyproline level. Our results indicated
that liposomal nanocurcumin and PL pro nanocurcumin
increased the level of hydroxyproline in the skin tissue.
In this study, doxorubicin, a chemotherapeutic drug
belonging to the anthracyline group, was used as a skin
ulcerative agent. It is one of the most important drugs
causing skin necrosis and, ultimately, severe ulceration,
with the incidence of extravasation injury being 0.1% to
6.5% [41, 59, 60]. This agent could affect the replication

and translation process, as well as activate the gene that
is responsible for cellular apoptosis. Eventually, the ulcer
caused by doxorubicin injection was broad and deep,
indicating that the ulceration model triggered by
doxorubicin was adequately reliable in gauging the
efficiency of liposomal nanocurcumin and PL pro
nanocurcumin [61]. According to our previous study, the
development of skin necrosis reached its maximum size in
one week [62]. In order to alleviate the triggered skin
lesion, the newly formed radicals in the cytosol and
interstitial space should be eliminated by potent
antioxidants for clinical practice. Therefore, DMSO was
used as a positive control in this study. Our results
indicated that liposomal nanocurcumin and PL pro
nanocurcumin significantly reduced ulcer size. However,
there were no significant differences in the healing effect
between liposomal nanocurcumin and PL pro
nanocurcumin-treated groups. In addition, burns can be
defined as tissue lesions resulting from exposure to
thermal sources, such as flames, hot surfaces and liquids,
extreme cold, chemicals, radiation, or friction [32]. In this
study, the model of superficial second-degree burns on
rats was successfully induced. Interestingly, liposomal
nanocurcumin showed better effects than PL pro
nanocurcumin on thermal burns in rats. In addition,
liposomal nanocurcumin significantly reduced infection,
compared to the vehicle-treated group, by improving the
macroscopic and histopathological structure. Furthermore, it did not affect the number of white blood cells
when compared to the normal control group. These effects
underscore the efficacy of liposomal nanocurcumin in burn
treatment. Thus, liposomal nanocurcumin is a more potent
wound-healing agent.
We also evaluated the systemic toxicity after the
application of topical liposomal nanocurcumin and PL pro
nanocurcumin on thermal burns in rats and skin ulcers in
mice. Long-term topical application can also affect the
systemic effects, especially when applied to open wounds
[63]. Overall, the findings of this study indicated that
topical administration of liposomal nanocurcumin and PL
pro nanocurcumin caused no significant change in the
general status, haematological parameters, and renal and
hepatic functions. Additionally, they did not alter the
histology of the liver and kidneys in animals. In oral
administration, curcumin did not exert acute, subchronic,
chronic toxicity, or reproductive toxicity in animals [11,
12, 64]. To date, there have been no studies evaluating the
systemic toxicity of nanocurcumin in open wounds. Our
results indicated that liposomal nanocurcumin and PL pro
nanocurcumin did not cause systemic toxicity in burned
rats and ulcerated mice. Hence, these studies suggest the
beneficial effects of liposomal nanocurcumin and PL pro
nanocurcumin and the potential of these formulations to
be developed as a potent nontoxic agents for treating skin
disorders. Overall, liposomal nanocurcumin and PL pro
nanocurcumin are valuable in the near future for wound
healing, but additional studies are required to provide
scientists with a deeper understanding.
CONCLUSION
The current study demonstrated that the topical
application of liposomal nanocurcumin and PL pro
nanocurcumin creams exerted healing effects on burned
skin in rats and doxorubicin-induced skin ulcers in mice.
Furthermore, liposomal nanocurcumin and PL pro
nanocurcumin did not cause systemic toxicity in the
experimental model. Liposomal nanocurcumin showed
better effects than PL pro nanocurcumin on thermal burns
in rats.
AUTHORS’ CONTRIBUTIONS
It is hereby acknowledged that all authors have
accepted responsibility for the manuscript’s content and
consented to itssubmission. They have meticulously
reviewed all results and unanimously approved the final
version of the manuscript.
LIST OF ABBREVIATIONS

PARTICIPATE
This study was approved by the Scientific Board
Committee of Hanoi Medical University, Vietnam (ref
number: IRB00003121).
HUMAN AND ANIMAL RIGHTS
All experimental protocols were in accordance with the
National Guidelines (reference number: 141/QD-K2DT).
This study adhered to internationally accepted standards
for animal research, following the 3Rs principle. The
ARRIVE guidelines were employed to report experiments
involving live animals and promote ethical research
practices.
CONSENT FOR PUBLICATION
Not applicable.
AVAILABILITY OF DATA AND MATERIALS
The data supporting the findings of the article is
available in the Zenodo Repository at https://zenodo.org/
records/11228442.
FUNDING
None.
CONFLICT OF INTEREST
The authors declared no conflict of interest, financial
or otherwise.
ACKNOWLEDGEMENTS
Declared none.
SUPPLEMENTARY MATERIALS
Supplementary material is available on the Publisher’s
website.

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Impressive deals are expected to flourish in the future thanks to the investments and cooperation of the Sharks. Nhat Hai New Technology Joint Stock Company (OIC NEW) is one of the science and technology enterprises that received an investment of up to 5 billion VND in the first season.

Receiving investment means receiving opportunities

At the end of 2017, OIC NEW with Nano Curcumin product participated in calling for investment in the business to receive VND 5 billion in exchange for 15% of shares and a commitment of 30% profit per year, with mortgage conditions. home. It was the enthusiasm of founder Luu Hai Minh – the determination to “plug in” that attracted the investment of Shark Phu as well as the attention of viewers.

 Ông Lưu Hải Minh tại Sharktank Việt Nam.

After more than 4 years, OIC NEW has established itself a strong position in the health food market. No longer struggling to find solutions to sell products to the market, now OIC NEW has built a network of agents from large hospital pharmacies to drug retailers nationwide. Products are also available on e-commerce platforms, reputable websites of distributors as well as enterprises’ own. Now mentioning Nano is referring to OIC NEW with wide coverage. In addition, according to founder Luu Hai Minh, not only domestic units, many distributors in the US, German and Japanese markets also propose to distribute products exclusively in these markets.

Continuous research and development

In 2017, OIC NEW brought to Shank Tank Vietnam only 1 new product to help overcome stomach disease to raise capital, but so far OIC NEW has researched and launched more than 5 other Nano products to support symptom relief. many chronic diseases such as liver, vestibular disorders, hemorrhoids, diabetes, blood fat,…

 Liquid Nano Curcumin in Sharktank.

The diversification in products helps OIC reach many customers, creating a biomedical Nano value chain – something that few medical and pharmaceutical businesses can do. With a lot of Nano research and products on the market, OIC NEW is proud to be the pioneer and leader in this technology and is recognized by the state as a Vietnamese science and technology enterprise.

Do not stop at the domestic but have to reach the international level

Not only the domestic market, OIC NEW directly competes in foreign markets such as the US, Japan, Singapore… Foreign partners choose to trust and import OIC NEW’s finished products. Despite difficulties in many import-export procedures in difficult markets, OIC NEW is confident with product quality that meets international standards to satisfy distributors as well as consumers. The presence in foreign markets is OIC’s first steps in entering a new market.  

Nano Curcumin OIC product on Amazon (USA).

Catching up with the global e-commerce trend (Global Selling), OIC NEW quickly put products on e-commerce platforms such as Amazon, Alibaba… From here, OIC can easily contact and cooperate with many retailers other international distribution. The large orders placed through e-commerce platforms are increasingly proving that the attraction of the product in the global market is very high and competitive on the new playing field.

Accompany – cooperate – develop together

In our country, in recent years, the field of health foods has been increasingly interested by consumers because of the trend of “prevention is better than cure”. This is a stepping stone for the development of the health food industry. OIC NEW inherits the values of science and technology brought, is increasingly researching and developing more new products, helping Vietnamese health.

After more than 4 years, after raising capital from Shark Tank, OIC NEW is considered as one of the enterprises with outstanding strides. Going up from researchers, now the crystallization of science is well received by consumers as a great success of the business. By the quality of those scientific crystals, OIC NEW is not only interested by investors but also receives the trust and love of customers. It can be said that the “blood” of founder Luu Hai Minh has now forged valuable “gold bars” for businesses. Shark Tank is like a launch pad, but how high and how long it can fly is still based on the relentless efforts of the business.

Rutin

Rutin is a flavonol, found in abundance in typical plants such as daffodils, passionflowers, buckwheat, black tea, and apples. Rutin has diverse biological activities and many pharmacological applications such as: antioxidant, anti-inflammatory, anti-viral and low toxicity with potential clinical applications, including anti-cancer effects. letter of this active substance.

Reports have shown that, at a dose of 120 mg/kg, Rutin has the ability to inhibit the growth of human leukemia tumors in an in-vivo mouse xenograft model. Rutin affects cell arrest and apoptosis, reducing the number of metastatic nodules and cytotoxicity. In addition to leukocytes, rutin also showed effects on many other cancer cell lines such as CRC colorectal cancer cells, B16F10 lung cancer cells, HTC liver cancer cells.

Chemical structure of rutin

However, rutin is a natural active ingredient that is poorly soluble in water (only 0.8 mg/mL) so it is only slightly absorbed from the gastrointestinal tract. Therefore, the oral bioavailability of rutin is only 20%, which is quite low compared to the target.

To solve this problem, a group of scientists from OIC NEW Company, represented by Inventor Luu Hai Minh, has chosen a nanoparticle-based drug delivery system approach. The advantage of nanoparticle-based drug delivery systems is that nanoparticle drugs can be engineered to achieve longer circulation times, better stability, improved concentration and internal drug accumulation, and increased drug availability. better ability to reduce toxicity to normal tissues.

The prenanoemulsion nanoparticle-based drug delivery system contains surfactants, surfactants and pharmaceutics, which can form nanoemulsions under conditions of digestive juices and intestinal motility after oral administration. The formation of rutin in the form of a nanoemulsion with a particle size of less than 100 nm can enhance drug solubility and absorption in the gastrointestinal tract. In addition, thanks to its stability, long circulation time and the ability to increase drug accumulation in cancer cells, Tween-80 and PEG-600 were selected as excipients to prepare rutin pre-emulsions in this study. . The requirement here is that the system should not be toxic to normal cells.

Rutin nanoemulsion system

To date, there have been few studies on the formulation of rutin in the pre-emulsion system and its cytotoxicity against lung and colon cancer. The research of inventor Luu Hai Minh and a group of scientists is considered a new invention for modern medicine. Inventor Luu Hai Minh said that, with a small size of 20-50 nm, the created rutin nanosystem has the potential to penetrate into cancer organizations. Then, under the influence of the environment, temperature, enzymes, etc., the shell will release, releasing nutrients without being destroyed or eliminated along the way.

The results of the particle size analysis showed that the rutin nanoparticles have a spherical shape with a smooth surface, which helps to have better mobility in blood vessels compared to other shaped nanoparticles.

The rutin particles have uniform size and shape, evenly distributed in the water emulsion. The average size of rutin nanoparticles is about 15 nm, which is very optimal and suitable for drug delivery into the body, thereby accumulating toxic compounds in cancer cells to weaken. Nanoparticles larger than 10 nm in size will not leak into the capillaries and are not eliminated by the one-time renal clearance process, thereby improving blood circulation time. At the same time, it is not captured by macrophages in the mononuclear phagocyte system and easily penetrates into human organs, especially tumors.

HR-TEN image of nano rutin after dissolving the pre-emulsion in water. Particle size is small, spherical and uniform

With these advantages, the process of preparing rutin nanoemulsions of Nhat Hai New Technology Joint Stock Company has been granted the Patent Utility Solution Patent No. 2490 by the National Office of Intellectual Property on 13/10/ 2020.

The team also conducted in-vitro tests on lung cancer cells, colon cancer cells and human fibroblast cells. By means of IC50 analysis, the research team determined that, within 72 hours, to inhibit over 50% of cancer cells, the concentration of rutin is: 154.8 μM for lung cancer cells and 154.8 μM for lung cancer cells, respectively. 251.5 μM with colon cancer cells.

Testing the water solubility of nano rutin vs rutin via the Tyndall effect

With the success of this study, the OIC NEW team of scientists will open a new direction in the application of rutin by nanotechnology to treat cancer. At the same time, it creates a premise for the development of new research on Nano technology based on this first published process.

Currently, the OIC R&D team and Inventor Luu Hai Minh are taking the final steps to announce Nano NO+ to help promote cardiovascular health; Reduce high blood pressure, prevent cardiovascular diseases such as atherosclerosis, stroke.

The study “Evaluation of cytotoxic effects of Rutin Prenanoemulsion in lung and colon cancer cell lines” was published in the Hindawi Journal of Science and Technology. Readers can watch it in full here.

Nhat Hai New Technology Joint Stock Company

Tel.: 1900 63 69 13

Address: 66 Trung Hoa, Cau Giay, Ha Noi

Website: https://oic.com.vn/

Why Nano and the Story of Capturing Technology

“Why Nano?” – This question is often asked to Mr. Luu Hai Minh – Chairman and Director of Research and Development of OIC NEW. And without hesitation, he replied: “Nanotechnology is the foundational technology for the 4.0 technology revolution. In the past years, from the time of its establishment in 2009, people mentioned Nano very recently because of the nano in activated carbon, nano in water purifier, nano silver…. but no one has mentioned Nano in biomedical and pharmaceutical chemistry”.

Similar to the story of putting pebbles in a jar, ordinary medicinal herbs are likened to pebbles, the size of these pebbles is too big to fill the gaps. But for nano-medicine, at the size of 20-30 nm, it will easily penetrate through the cells and go deep into the body, increasing its absorption into the blood and helping the medicinal herbs to promote optimally. its use. Many people worry that the use of Nano technology will lose the properties of medicinal herbs. However, with OIC NEW’s technology, the essences of medicinal herbs are always preserved in use and benefits for users.

Doing science is synonymous with research and development

In 2016, OIC NEW launched the first product, Nano Curcumin in liquid form. This is considered a new breakthrough in the preparation of nano curcumin, when the market for nano curcumin products to support the stomach emerged as a fever. Not following the path, OIC NEW chose the quality solution as the top priority and the OIC Nano Curcumin Solution was born after 7 years of research. Then, continuously from 2016 -2020, OIC NEW created a Nano wave with more than 50 researches and launched many products extracted from nature to help overcome many current diseases such as: liver, gallbladder, bone. joints, blood fat, cerebral circulatory insufficiency, cardiovascular, male physiology, female physiology, fat loss, diabetes, …

OIC NEW received the title of the main industrial product of Hanoi city

With a series of massive research projects, OIC NEW has been awarded Enterprise Awards for many years by the Association of Science and Technology, Hanoi People’s Committee. Not only that, Nano OIC products are also highly appreciated by experts and are distributed at major agents, hospitals, and pharmacies across most of the provinces. The belief that OIC NEW brings to customers is the real value of “true and on point” scientific research.

OIC NEW always carries with it the mission of a scientific enterprise. Therefore, after grasping biomedical Nano technology, OIC NEW focuses its resources on research and product development. Inventor Luu Hai Minh once shared that “in the future, it is possible to make Vietnamese herbs and medicinal herbs help overcome many chronic and malignant diseases”. In addition to products with materials imported from abroad, OIC NEW always appreciates Vietnamese medicinal herbs, familiar plants of Vietnamese people in traditional medicine. Changing the view of traditional medicinal herbs with low or slow effects of Vietnamese people. When applying Nano technology to these products, OIC confidently turns Vietnamese plants into typical products in the world health care market. As proof of that, OIC NEW has been successful with Nano health care products from natural herbs branded Made in Vietnam and reached international level with major partners in the US, Japan, Singapore, Malaysia, Greece, ….

New journey – new mission

After more than 11 years of asserting itself in the market and receiving the trust of customers for its products, OIC NEW continues its research and development journey, constantly striving to produce “golden” products for customers. health. Not only in the field of Biomedical Sciences, OIC NEW has been implementing other Nano application researches in beauty, agriculture, environment, etc. to create greater value, to thoroughly exploit the uses of Nano. stronger.

OIC NEW’s vision is from the core Nano technology, which can create an ecosystem, a network that connects individuals and businesses from product development to commercialization to the market. Because OIC NEW’s desire is that more and more customers can choose for themselves high-value, effective and reputable products.

“OIC’s responsibility is the responsibility of a new age scientist.”

Nhat Hai New Technology Joint Stock Company

Tel.: 1900 63 69 13

Address: 66 Trung Hoa, Cau Giay, Ha Noi

Website: https://oic.com.vn/

What is Gamma Oryzanol? 

Since ancient times, the traditional medicine of Asian countries has used brown rice – rice with the brown bran intact as a remedy for health and effective treatment of diseases. Thanks to the development of science and technology, researchers have discovered the mystery of the brown rice grain lies in the brown bran layer that surrounds it. This shell contains a large amount of vitamins, minerals and antioxidant nutrients, especially gamma oryzanol – which has the effect of slowing down the aging process of cells, reducing bad cholesterol, preventing and stabilizing blood sugar. Therefore, gamma oryzanol is recommended by many diabetes doctors around the world to regulate blood sugar in the body, protecting the health of patients.

Gamma Oryzanol – The “miracle” use for diabetes

Improve blood sugar

A study by the Harvard School of Public Health came to the following conclusion: “If you replace ⅓ of white rice eaten in your daily diet with unpolished brown rice, the risk of type 2 diabetes will be significantly reduced. “. Indeed, Gamma Oryzanol found in brown rice is an important factor that helps improve blood sugar significantly for patients. It should be noted that the reason why Oryzanol can lower blood sugar is because of its ability to regulate autonomic nerves, improve the body’s immunity and improve insulin sensitivity to body. Gamma Oryzanol helps maintain plasma glucose levels, lowering the AUC for insulin. Improves insulin resistance and lipid metabolism. Diets containing gamma oryzanol help reduce fasting and regional blood glucose.

Improve high cholesterol levels 

Heart disease is caused by cholesterol build-up forming plaques that block blood vessels leading to heart disease. Gamma-Oryzanol in rice bran has the ability to reduce bad cholesterol in the blood.

Increased cholesterol in people with diabetes

Through many studies, experts have concluded that a healthy diet with rice oil can prevent cardiovascular diseases such as blood fat, blood pressure, stroke, etc. This use mainly comes from nutrients. substances such as Gamma Oryzanol, vitamin E and 27 other phytosterols. Research published in the European Journal of Nutrition showed that, after 2 weeks of use, the nutrient Gamma Oryzanol in rice oil helped reduce the amount of bad cholesterol in the blood of test participants by 11.9%. This helps prevent dangerous complications caused by diabetes, one of which is cardiovascular complications.

Antioxidant

The phenomenon of increased oxidative stress is considered to be the mechanism causing diabetes and related dangerous complications. In diabetes, the increased production of free radicals, especially ROS, is caused by prolonged hyperglycemia. The addition of an exogenous nontoxic antioxidant such as gamma oryzanol plays a protective role in diabetes. Gamma Oryzanol has been shown to reduce oxidative stress and reduce glycosylated hemoglobin levels in diabetes, including type 2 diabetes. In addition, studies have also shown that gamma oryzanol can reduce the risk of diabetes. Fat-induced hyperglycemia by dietary excretion and hepatic glucose-regulating enzyme activities.

The gamma oryzanol molecules play a potential role in such an anti-diabetic target, but the absorption efficiency in the raw form is not high. That is, if the patient normally uses rice bran oil or even pure gamma oryzanol, it must be used in large quantities for a very long time to be effective, because the characteristic of most natural medicinal herbs is the degree of toxicity. Poor water solubility, easily eliminated from the body. This is also a problem that has caused headaches for scientists in recent times.

So is there a way to use Gamma Oryzanol effectively for diabetics?

A group of scientists from Nhat Hai New Technology Joint Stock Company recently found a method to increase the absorption of gamma oryzanol by hundreds of times, thanks to the application of nanotechnology in the preparation process. The raw medicinal essences usually exist at the micrometer size, but by nanochemical method, gamma oryzanol is brought down to the microscopic nano size of only 20-50nm. At this microscopic molecular size, nano gamma oryzanol will be easily dissolved, easily absorbed, and concentratedly distributed in the affected areas. Since then, the absorption efficiency increases steadily and sustainably, without wasting medicinal herbs or causing unwanted side effects.

Having mastered nanotechnology in the preparation of nano gamma oryzanol, Nhat Hai New Technology Joint Stock Company has supplied to the market Nano Megumi Health Supplement to support the treatment of diabetes. Selecting the source of gamma oryzanol from Japan, and imported ingredients meeting international pharmacopoeia standards, Nano Megumi effectively supports the control, management and regulation of blood glucose levels in people with diabetes. ; Strong anti-oxidant, helping the body to have better resistance. In addition, Nano Megumi also supports lowering blood sugar, helping to reduce the risk of cardiovascular complications due to diabetes. At the same time, the process of preparing Nano Gamma Oryzanol microemulsion system has been registered as a Patent at the National Office of Intellectual Property. Products are manufactured on modern technological lines, strictly tested before being distributed to the market. Nano Megumi is highly appreciated by users and medical circles for its effectiveness in supporting the treatment of diabetes.

This supplement is not a medicine and is not meant to replace medicine. Patients who are war invalids and disabled people need to consult a doctor for more instructions.

Diabetes – the silent killer

According to statistics, in our country, 1 in 11 adults will have a risk of diabetes, 65% of people do not know they have the disease. The number of people with diabetes in our country is predicted to increase to 7.7% of the population by 2045. Untreated diabetes can cause blindness, nerve damage leading to infections that require amputation. , stroke, heart attack. It is also the leading cause of death in developing countries. The disease has a very rapid development rate in today’s society.

Active ingredient gamma oryzanol for diabetics

Using natural herbs in repelling chronic diseases is a trend that is preferred by experts as well as users because of its safety and benignity. Pharmacological properties of active ingredients in a number of medicinal herbs have been proven effective and clinically tested. This is an opportunity for scientists to develop many health care products from this unique source of available materials.

Rice bran oil

And Gamma Oryzanol is an active ingredient that has been studied in this direction. By experimental studies, Gamma Oryzanol has been proven to be effective in supporting blood sugar control, lowering blood sugar, preventing complications by increasing insulin sensitivity; support to prevent reduction of adiponectin – the risk of cardiovascular complications; Reduce inflammation and infection in diabetics. At a time when diabetes has almost no cure, patients have to accept living with this disease for the rest of their lives, this new discovery will be good news for diabetics.

Gamma Oryzanol is an ingredient in rice bran oil with a very low content of only 1-2%. This active ingredient is widely used in Japan, Europe and America. Gamma Oryzanol is currently mostly in powder form, has a white or light yellow color, is almost odorless and has the highest purity of 98%. However, the disadvantage of most natural herbs, not except gamma oryzanol, is poor solubility. When mixing gamma oryzanol powder into water, it will clearly see the layering, insoluble in water, settling to the bottom of the cup. This proves that if using gamma oryzanol in normal raw form, the absorption into the body is not significant, not to mention for people with poor physical condition, the active substance will be eliminated.

New nanotechnology advancement, enhancing gamma oryzanol efficiency

Understanding the importance and great advantages of gamma oryzanol with diabetes, and at the same time, overcoming the disadvantages of old methods, scientists at Nhat Hai New Technology Joint Stock Company (OIC NEW) With the Inventor, Dr. Luu Hai Minh is the representative who has found a new method, which is the application of nanotechnology.

The main purpose of nanochemical method is to increase the diffusion, absorption and permeability of active substance gamma oryzanol in order to improve the ability to cross the blood-brain barrier and increase the bioavailability of this active substance in diabetes mellitus. Disconnect the road.

Gamma oryzanol nanoemulsion system

Inventor Luu Hai Minh and the research team of OIC NEW company have successfully launched the process of making gamma oryzanol nanoemulsions. With this process, the obtained gamma oryzanol particles have a microscopic particle size of less than 50 nanometers (nm), the pharmacological properties of the medicinal herbs are still preserved, and at the same time promote absorption into the blood and cell.

Gamma oryzanol nanoparticles, in addition to reaching small particle size, are also encapsulated by 3 “coats” of bases, achieving the following criteria: stability, sustainability, and not being destroyed by acidic gastric juices on the way to the small intestine. , precise target direction to the damaged site. The active time of the drug is also increased, the ability to penetrate the biological cell membrane. This helps to make full use of medicinal herbs, without wasting and reducing dosage, reducing costs for consumers. The effect is then increased many times compared to conventional gamma oryzanol.

In terms of visual perception, gamma oryzanol nano solution, when mixed with water, does not layer, completely soluble in water with a very clear color.

Gamma Oryzanol in nano form will act directly on pancreatic cells, thereby promoting the production of glucose-stimulating insulin; At the same time, it helps to improve the function and survival of pancreatic beta cells, helps to reduce and stabilize blood sugar, and reduces dangerous complications caused by diabetes. Especially thanks to its benign nature from natural herbs, nano gamma oryzanol does not cause side effects on the digestive organs, liver, and bile.

Inventor Luu Hai Minh shared: “OIC NEW’s research team has completed more than 30 patent studies on nanotechnology from many domestic and foreign natural medicinal herbs, including 10 patents. Preparations and Solutions are useful, but gamma oryzanol can be considered a special active ingredient. Because this active ingredient was supplied to us by Oryza company – a company specializing in Japanese natural ingredients for more than 100 years, and proposed to make nano gamma oryzanol. This is the joy and pride of the research team when it is recognized for the value of technology that can bring to the market a truly quality product.”

Nano Megumi health supplement is extracted from gamma oryzanol essence from rice bran oil – imported from Japan, using advanced nanotechnology, preparing micro-particle size of only 20 – 50nm, fast absorption and increase absorption capacity many times compared to using normal gamma oryzanol. Uses: – Support to reduce blood sugar – Support to reduce the risk of cardiovascular complications due to diabetes Target users: – Diabetics – People with high blood sugar Trader responsible for product quality and distribution: Nhat Hai New Technology Joint Stock Company Address: No. 66, Trung Hoa, Cau Giay, Ha Noi Manufactured by: Nam Ha Pharmaceutical Joint Stock Company Hotline: 1900 63 69 13 This supplement is not a medicine and is not meant to replace medicine.

The Lunar New Year is one of the most important holidays for Vietnamese people, a time when everyone gathers together for cozy reunion meals. This is a beautiful tradition during Lunar New Year.

Hearty meals have become a specialty of Lunar New Year, but it also has a lot of potential dangers when we overeat, get out of control and lead to various negative consequences for our health. such as: obesity, hyperglycemia, diabetes complications, increased risk of diabetes and increased risk of heart disease…

Eating too much will cause blood sugar to spike because the body starts to overcompensate and produce more insulin than usual to keep blood sugar in the normal range. It is a great concern for people with diabetes before having high blood pressure and extremely dangerous complications of the disease.

Before worrying about health when eating too much on New Year’s Day, what will be a good solution for people with diabetes

Notes on the diet:

Never skip meals to avoid hypoglycemia. Eat several small meals throughout the day. This is quite suitable for Lunar New Year holiday when most do not have a fixed meal, every time they meet friends, they will sit at the table to eat.

In the Lunar New Year, there are often many fried dishes, sticky foods (banh chung, banh tet, sticky rice …). People should add more green vegetables and use low-sugar fruits for dessert (oranges, tangerines, grapefruit…).

Jams, confectionery and carbonated soft drinks used quite a lot during Lunar New Year are foods with high sugar content. Diabetics should not eat this food group. Consider using a sugar substitute when using coffee or tea. Use filtered water or tea instead of carbonated soft drinks.

Alcohol on New Year’s Day is inevitable, but this is the cause of hyperglycemia because alcohol prevents glycogen synthesis, thereby affecting the liver’s metabolic ability. According to experts, diabetics should only consume 200ml of wine per meal. Absolutely do not drink alcohol without eating, do not take diabetes medicine with alcohol. For cases of insulin injection, after drinking alcohol, patients should check their blood sugar before going to bed, if blood sugar is lower than 6mmol/l, they must have additional snacks.

Good food groups for people with diabetes include: vegetables such as cauliflower, carrots, green vegetables, peppers, tomatoes, potatoes, corn and green beans; Fruits include oranges, melons, berries, apples, bananas and grapes. In addition, people with diabetes should eat foods with heart-healthy fats like avocados, nuts, and healthy fish like salmon, tuna, mackerel, canola oil, and olive oil.

The solution comes directly from the use of natural herbs

People with diabetes, once diagnosed with the disease, often think that they have to “live with the flood”, because the disease is long-lasting and difficult to cure, often requires long-term treatment with western medicine, causing fatigue and persisting. At many risks of dangerous complications, especially during each Lunar New Year holiday, the fear of high blood sugar increases. Therefore, at present, the use of natural herbal products in supporting the treatment of diabetes is being prioritized by patients because of the effectiveness as well as the benign and safe products that the product brings. . One of them is the gamma oryzanol component in rice bran oil.

Gamma Oryzanol is the main active ingredient extracted from rice bran oil, which has been proven by world studies to be effective in preventing and stabilizing blood sugar. However, because of its low solubility, poor absorption, and low therapeutic effect in its raw form, it makes diabetics struggle to know how to use it to take advantage of the medicinal properties of this precious medicinal herb. to the maximum extent possible.

With its methodical scientific research, Nhat Hai New Technology Joint Stock Company is the first unit to successfully prepare Nano Gamma Oryzanol, which increases its effectiveness hundreds of times compared to conventional Gamma Oryzanol. With ultra-small, targeted nanoparticle size, Health Supplement Nano Megumi helps to reduce blood sugar and reduce the risk of cardiovascular complications caused by diabetes. Thanks to the source of pure ingredients imported from Japan, and the exclusive nano formula, Nano Megumi is a reliable, safe and suitable product for diabetics to choose for the New Year. now on.

Website: http://nanomegumi.vn/

Hotline: 1900 63 69 13

*This supplement is not a medicine and is not a substitute for medicine.

The health supplement market is now full of flowers, which means that poor quality supplements are rampant, management agencies are difficult to control, and consumers are confused about finding quality products that are in accordance with their needs.

Ms. Van (Hanoi) said that she has used health supplements for decades to support the treatment of many diseases. According to her experience, nowadays there are many products with very attractive forms of advertising, hitting the psychology of patients, but when learning about the origin, origin, production facilities as well as the Certificates, inspection and testing documents are incomplete. For the average buyer, this is difficult to distinguish.

The elaborate investment in research projects protected by state agencies, as well as the assurance of certificates and certifications on the origin of raw materials for production have contributed to solving the problem of supply-demand in the health supplement market today with the goal that Vietnamese people give priority to using Vietnamese products. For example, the introduction of Health Supplement Nano Megumi containing Nano Gamma Oryzanol extract from rice bran oil. There have been many studies and many scientific conferences conducted to discover and announce the effects of gamma oryzanol in the treatment of diabetes in rice bran oil.

Many studies have shown that the gamma oryzanol in rice bran oil is beneficial for diabetes.

Gamma Oryzanol in rice bran oil is known for its strong antioxidant properties, capable of blocking the absorption of cholesterol in intestinal cells, preventing the development of atherosclerotic plaque. Especially with diabetes, gamma oryzanol is an extremely beneficial active ingredient in improving insulin sensitivity, improving blood sugar levels, preventing the reduction of adiponectin – a risk factor for diabetes, and while enhancing glucose uptake by fat cells. Long-term use of gamma oryzanol also boosts muscle strength, improves skin health, and boosts the immune system.

Rice bran oil contains a lot of gamma oryzanol, which improves blood sugar

Currently, on the market, there are a lot of medicinal products and health supplements for diabetes, but there is no product from gamma oryzanol that takes advantage of the great values ​​for diabetics that this medicine brings. . Diabetes is a relatively sensitive chronic disease, so the presence of Nano Megumi product has contributed to bringing a new and more effective solution in reducing and regulating blood sugar, and at the same time extracted from nature. ensure health and safety for users.

Health Supplement Nano Megumi is a product of Nhat Hai New Technology Joint Stock Company – a company with more than 11 years of experience in the research and production of health care products from applied natural medicinal herbs. Nanotechnology, Nano Megumi is also produced based on the Process of preparing Gamma Oryzanol nanoemulsion system, which has been patented at the National Office of Intellectual Property No. 1-2020-00377.

Nano Megumi is a product of Nhat Hai New Technology Joint Stock Company

With the source of the raw material is pure gamma oryzanol up to 98% from the Japanese Oryza house with hundreds of years of experience, Nano Megumi ensures the purity, purity, safety, and minimal side effects of medicinal herbs. With exclusive technology, the first gamma oryzanol nanochemical technology on the market, reduces the molecular size of gamma oryzanol to a form that is smaller than the cell membrane, thereby increasing the efficiency hundreds of times compared to conventional raw materials.

Nhat Hai New Technology Joint Stock Company (OIC NEW) is currently the leading unit in research and production of Nanotechnology products from natural medicinal herbs. With Nano Megumi product for diabetics, Nhat Hai New Technology Joint Stock Company has contributed a new quality product in the Vietnamese health supplement market, with a long-term mission: True Nano – Because of Vietnamese health, OIC NEW brand is now not only available in the domestic market but also in countries such as Singapore, Cambodia, the US (Amazon), …

This supplement is not a medicine and is not meant to replace medicine. Patients who are war invalids and disabled people need to consult a doctor for more instructions.

Why is it difficult to cure diabetes?

Science is developing more and more, but until now, diabetes has not been completely cured, because the causes of the disease are very complicated.

With type 1 diabetes, the only hope of a cure is a pancreas transplant. Because the place of production of insulin is the islet of the pancreas that has been destroyed and is unable to secrete insulin.

With type 2 diabetes, the hope of a complete cure is almost zero. Because pancreatic insufficiency combined with insulin resistance and cellular molecular metabolic disorders make it difficult to control blood sugar and the risk of complications is high.

The suffering of people with diabetes is that it is very difficult to control blood sugar

It is difficult to cure, but the worrying thing is that the state of diabetes in Vietnam is at an alarming rate, even among the top countries with the highest number of people with diabetes in the world.

Golden medicinal herbs bring joy to people with diabetes

After a lot of intensive research by a series of scientists around the world, it has been discovered: Gamma oryzanol (a component of rice bran oil) brings a lot of benefits to health in general and diabetes in particular.

Các nghiên cứu về Gamma oryzanol tiêu biểu có thể kể đến là:

A study in rats with type 2 diabetes showed that: Gamma oryzanol increased insulin sensitivity in rats.

Research by scientist Qureshi et al in 2000 showed that: Gamma oryzanol has been shown to have cholesterol-lowering and antioxidant properties.

Research by scientist Siddiqui and colleagues in 2010 published: Gamma oryzanol reduced blood sugar and HbA1c index of diabetic rats (both type 1 and type 2).

Research by scientist Jun et al in 2004 on diabetic patients showed that: Gamma oryzanol reduces fasting blood sugar levels, while increasing insulin sensitivity.

Gamma oryzanol is extracted from rice bran oil

Overall, most studies show 4 prominent uses for Gamma oryzanol:

• Controls blood sugar levels by helping to improve the function of pancreatic beta cells (cells that release insulin).
• Lower blood sugar by helping to promote insulin secretion, increase insulin sensitivity, and also stimulate fat cells to increase glucose absorption.
• Reduce the risk of diabetes complications through good blood sugar control
• Antioxidant, repels free radicals, protects cells.

It is because of these effects that Gamma oryzanol has been evaluated as a golden medicinal herb in the health care industry and is sought after by many famous pharmaceutical companies in the world.

Where can I buy and use this precious medicinal herb in Vietnam?

Gamma oryzanol is extracted from rice bran oil, so you can buy it in Vietnam. However, experts note, Gamma oryzanol molecules are difficult to absorb because they are insoluble in water and easily destroyed by gastric juice. The proposed solution is: applying nanotechnology (ultra-small size, only from 20-50nm) to produce Gamma oryzanol to increase absorption through cell membranes.

Realizing the role and urge to bring joy to diabetics, the R&D team of Nhat Hai New Technology Joint Stock Company (OIC) has researched and prepared the Gamma oryzanol nanoemulsion system. With 11 years of experience in research and application of nanotechnology in the preparation of natural medicinal herbs, the OIC team of experts has been able to prepare Gamma oryzanol molecules with a very small nano size, only from 20-50nm, easy to use. Water soluble, readily permeable to cell membranes. Nano Gamma oryzanol is also packaged to protect against the destruction of gastric juices in the digestive tract, to reach the exact location of the injury and heal faster.

Nano Gamma oryzanol is the main ingredient in Nano Megumi – a health supplement for diabetics.

Nano Gamma oryzanol is the main ingredient in Nano Megumi

Special advantages of Nano Megumi for people with diabetes

The strength of Nano Megumi compared to other diabetic products on the market is that it has a 2-in-1 mechanism of action: Lowering blood sugar, good blood sugar control, and improving cell function. release insulin, protect cells from exhaustion.

As a result, Nano Megumi has the effect of supporting blood sugar reduction, good blood sugar control, helping to reduce the risk of complications from diabetes, especially cardiovascular complications.

These are the reasons why Nano Megumi is highly appreciated by endocrinologists and trusted by many diabetics!

*This supplement is not a medicine and is not meant to replace medicine. Patients who are war invalids and disabled people need to consult a doctor for more instructions.

What is nanotechnology?

In a word, nanotechnology is a technique related to the analysis and fabrication of molecular structures by reducing the shape and size to nanometers (nm). 1nm = 1 millionth of a millimeter.

Nanotechnology is being applied in all areas of life, from electronics, food to medicine. Many experts have called nanotechnology a revolution in medicine because of the great achievements that this technology brings to human health..

Clinical practice has proven that nano-sized medicinal molecules help increase the body’s ability to absorb, thereby increasing the effectiveness of treatment as well as supporting treatment by hundreds of times.

Some of the preeminent effects of nanotechnology-applied health supplement and medicinal products are:

• Absorbs quickly, no waste
• Targeted impact
• Does not affect other tissues or cells
• Few or no side effects.

Nanotechnology is a revolution in medicine

Application of nanotechnology in diabetes support products

R&D experts of Nhat Hai New Technology Joint Stock Company, with 11 years of experience in research and application of nanotechnology in the preparation of natural medicinal herbs, have successfully prepared Gamma oryzanol at the nano level to produce product life of Nano Megumi.

Gamma oryzanol is the main active ingredient extracted from rice bran oil, which has been proven by many studies around the world for its effective use in preventing and stabilizing blood sugar. In developed countries such as the US, Japan, and Korea, this medicinal herb is also widely used.

However, Gamma oryzanol molecules have the disadvantage of being poorly absorbed because they are insoluble in water and easily decomposed by gastric juice. Therefore, the use efficiency is not high.

If so, shouldn’t people with diabetes benefit from Gamma oryzanol?

The inventor, Dr. Luu Hai Minh – who holds more than 7 patents and useful solutions for health protection products using nanotechnology by the National Office of Intellectual Property, has diligently researched and found a superior solution: Applying nanotechnology to prepare Gamma oryzanol. Gamma oryzanol molecules are analyzed at a very small nanoscale, only from 20-50 nm, easily soluble in water, easily permeable to cell membranes. From here, Gamma oryzanol combines with other special ingredients produced on modern technological lines to ensure all quality criteria, to produce Nano Megumi products.

Gamma oryzanol has been researched and developed into Nano Megumi

Gamma oryzanol in Nano Megumi easily crosses the digestive barrier, is not destroyed by gastric acid, easily enters the intestinal tract, precisely targets the injury site and heals. As a result, the effectiveness of using Nano Megumi is not only high but also sustainable and long-lasting.

When blood sugar levels are ensured, diabetes is well controlled, will prevent and limit dangerous complications, and the patient’s life will also be longer.

What are the benefits of Nano Megumi, who should use it?

Nano Megumi has special uses:

1. Hypoglycemia (due to promoting insulin secretion, increasing insulin sensitivity)
2. Reduced risk of diabetes complications (due to safe blood sugar control)
3. Antioxidant (protects cells, avoids oxidative reactions).

People who should use Nano Megumi are:

• Diabetics need to control blood sugar
• People with diabetes want to prevent complications, especially cardiovascular complications
• People with high blood sugar levels want to lower their blood sugar to a safe level.

Nano Megumi is a product specifically for people with diabetes

Where can I buy Nano Megumi??

Health Supplement Nano Megumi has been patented at the National Office of Intellectual Property, registered for product quality standards, and sold at agents nationwide.

If you need more advice on products or diabetes conditions, you can contact Hotline 1900636913 for free, timely advice.

Small and medium enterprises have the opportunity to access the e-commerce platform

According to statistics of the Department of E-commerce and Digital Economy (Ministry of Industry and Trade), the size of Vietnam’s B2C e-commerce market, including the revenue of all goods and services sold through e-commerce channels, has continuously increased in the last 5 years. past year. The value of a person’s online shopping has also changed rapidly, from $160 in 2015 to $225 in 2019.

However, many small and medium enterprises have good products but struggle not to know how to make brands, only outsourcing for customers by selling directly to traders or looking for customers at international fairs and exhibitions. they are not interested in e-commerce or businesses do not have knowledge of international e-commerce.

As a bridge, Industry and Trade Newspaper has connected to help start-ups innovate on e-commerce platforms. Accordingly, in the series of activities of the Techfest Innovation Start-up Day 2020, at the Workshop “Promoting successful digital transformation startups on the e-commerce platform”, OIC New Company is one of 6 units were selected to sign a cooperation agreement with Procom Vietnam Joint Stock Company (iExport). This is a company that acts as a cross-border trade bridge to help small and medium enterprises (SMEs VN) export successfully on e-commerce platforms.

Mr. Trinh Hoang Linh – CEO of iExport – said: “Many business owners know about international e-commerce but have no experience and do not know how to do it, so when they start working, they face many difficulties leading to the implementation of international e-commerce. ineffective, eventually they will think that e-commerce is ineffective and give up on it”.

With 10 years of experience in the field of export promotion based on technology and e-commerce, iExport’s team has helped many businesses take advantage of technology platforms to go fast and far on their export journey. – Mr. Trinh Hoang Linh shared more.

The signing ceremony of a memorandum of understanding to support the connection of innovative start-up products to the e-commerce platform between representatives of the Market Development Department and enterprises – Ministry of Science and Technology, Industry and Trade Newspaper and OIC New

Signed cooperation agreement to bring OIC New’s products to the e-commerce platform

Established in 2009, Nhat Hai New Technology Joint Stock Company (OIC New) operates in the following fields: Research, transfer and manufacture products applying Nano technology in the fields of biomedical, industrial, agricultural industry, environment. OIC New’s research department has focused on product research and development. It is the cross-section of research and production transfer of products applying Nano technology that is an opportunity and is expected to be a sustainable direction for the development of OIC New.

Currently, the company holds many manufacturing processes and nanotechnology patents; manufacturing and applying nanotechnology in production with the intention of developing potential subsidiaries that can put OIC New’s nano products into production. The company has 6 products including: Liquid Nano Curcumin OIC – Support treatment, reduce symptoms of stomach ulcers, duodenal bulb; Nano Silymarin OIC: Supports the treatment of liver diseases, enhances liver function, protects liver cells. Nano Rutin OIC: Support treatment of hemorrhoids, varicose veins, blood pressure, stroke prevention; Nano Ginkgo Biloba OIC: Supporting the treatment of cerebral circulatory insufficiency; Nano Resveratrol OIC: Support to reduce blood cholesterol, help reduce blood pressure; Nano Megumi OIC: Support to reduce blood sugar, reduce the risk of cardiovascular complications due to diabetes. Most recently, the product Nano Megumi supports people with diabetes.

New product Nano Megumi of OIC about supporting diabetic patients

The signing of a memorandum of understanding to support the connection of innovative start-up products to an e-commerce platform with iExport will promote the quality service experience of OIC New’s customers. With online shopping activities, online payments, promotions are updated regularly along with many other supports. In addition, in order to promote the exploitation and promotion of Nano health care products, OIC New is currently implementing international trading activities of Nano OIC products at Alibaba, ECVN, etc. ..

In the coming time, OIC New strengthens digital transformation for business activities, promotes the promotion of products to international markets by accessing e-commerce platforms, towards the goal: “Bring Vietnamese wisdom to reach out to the international market.” out into the world”. With the rapid development of the world’s Science and Technology in the field of nano as well as the determination of the Vietnamese Government in investing in high technology. OIC New strives to achieve revenue from nano products about 1 billion USD/year by 2025.

Vietnam’s high-quality Nano products reach out to the world

Nhat Hai New Technology Joint Stock Company was established in 2009 (formerly known as Information Technology Research Center) and is a leading science and technology enterprise in Vietnam that successfully applied Nanotechnology in the biomedical field. With a team of good, experienced engineers and leading experts in the field of Nano, OIC NEW’s vision is to bring Vietnam’s high-quality Nano products to the world.

Inventor Luu Hai Minh

With special self-research and exclusive production machines, OIC NEW is proud to be the first and only unit to successfully prepare nanoparticles from natural compounds with the smallest size on the market today. 5-30nm), with USP&EP international pharmacopoeia standard ingredients – and the know-how of formulas, Nano products are perfectly absorbed into cells, bioavailability is hundreds of times higher than conventional products. Usually, it is both effective and safe for the body.

All Nano products from natural medicinal plants of OIC NEW are granted a Patent or a Utility Solution Patent by the National Office of Intellectual Property for the Preparation Process – a clear demonstration of the research potential. research, development and output quality for products. In addition to the Patents and Utility Solutions, Inventor Luu Hai Minh and his collaborators at the OIC R&D center also have international articles published in specialized journals on Nanotechnology in the UK as well as articles about the application of Nano OIC products in supporting cancer treatment published in the Journal of Practical Medicine.

Inventor Luu Hai Minh is the author of 35 registered patent applications and has been granted 2 invention patents and 5 utility solution patents by the National Office of Intellectual Property. The raw materials for the production of products are mainly imported from countries around the world such as the US, Europe, Japan and especially the natural materials of Vietnam.

Target 100 patents on natural compounds

The first direction with nanotechnology is in the fields of agriculture and industry, but now, OIC NEW has been and is one of the pioneers in the nanotechnology of natural medicinal plants with immense potential. big. With a strategic vision and a scientific and bold organizational method, the inventor Luu Hai Minh – Chairman of the Board of Directors of Nhat Hai New Technology Joint Stock Company has built the OIC NEW brand with the following products: The first Nano product line in the market and the world.

Up to the present time, OIC NEW has more than 50 researches on Nano products being commercialized in the market. From standard herbal ingredients, with scientific evidence of effectiveness, OIC NEW is the first unit in Vietnam and in the world to make nano preparations with the smallest particle size on the market to support the treatment of diseases. treatment of common chronic and malignant diseases today.

Inventor Luu Hai Minh’s goal is that by 2030, his company will launch 100 patents on natural compounds that have the effect of improving health and preventing disease. “Due to many problems, Vietnamese products have not been exported to the world. I hope with the wisdom of Vietnam and my collaborators to launch 100 patents to be able to apply Vietnamese natural products for export,” said Inventor Luu Hai Minh.

Digital transformation – General trend of international business

According to Inventor Luu Hai Minh, digital transformation is a business model transformation that requires a product transformation, which is very suitable for OIC. Grasping the future, since 2009, Inventor Luu Hai Minh has transformed his business model from information technology to focus on researching Nano technology products.

In the early stages of transformation, the company faced many difficulties because the direction was not yet available, the technology was unknown, but with the determination of the leaders, currently, OIC has 25 products sold in the market. America, Amazon, Alibaba, Vietnam,…

“This is the general trend of international business, as an alumnus of Foreign Trade University, I understand what needs to be done for the company to grow and be strong,” said Inventor Luu Hai Minh. .

Before starting a business, Mr. Hai Minh was an IT, when he decided to start a business he was opposed by his family and friends. Although his friends invest in real estate and securities, he chooses his own path by investing completely both capital and knowledge in the field of Nano technology. Because of too much investment, he is determined not to give up, also because of that he has made remarkable achievements. After more than 10 years choosing the path of Nano Technology.

OIC achievements are certified by consumers

With the principle of “Prestige – Internationally equivalent quality”, Nano OIC products always have to go through extremely strict evaluation stages, from controlling input materials to meet quality standards, the ingredients must meet the USP/EP international pharmacopoeia standards of the US and EU; to testing the product quality criteria of the National Institute of Food Hygiene and Safety. Therefore, OIC NEW’s products are trusted and used by customers, domestic and foreign partners and successfully present in 63 provinces and cities in Vietnam and major markets in the world such as: USA , Germany, Japan, Cambodia, Singapore, Angola, etc. The company has received the certificate of exporting goods to the US market by FDA organization.

Continuously from 2016 up to now, Nhat Hai New Technology Joint Stock Company has received the Certificate of Merit and the Rotary Flag from the Chairman of the Hanoi People’s Committee for its excellent performance in production and business activities, contributing to the development of Vietnam. socioeconomic of the City. Awarded by the Ministry of Science and Technology for great achievements and works in Science and Technology activities. OIC NEW’s products have been certified as Vietnamese Goods loved by consumers for many consecutive years and are in the Top Key Industrial Products in Hanoi.

“Don’t expect investors’ money, but protect investors’ money. If you want to work towards success, never give up,” said Inventor Luu Hai Minh.