42. Nano Sesamin

Nano Sesamin has a size of 25-50 nm, completely retaining the chemical structure and biological nature of Sesamin, providing a product with high safety, outstanding efficiency and speed.

Black sesame seeds are small but their uses are magical!

Nano Sesamin has a size of 25-50 nm, completely retaining the chemical structure and biological nature of Sesamin, providing a product with high safety, outstanding and fast effectiveness. Nano Sesamin is completely soluble in water, increasing bioavailability to the maximum level.

What is Sesamin?

  • Black sesame seeds (also known as black sesame) have the scientific name Sesamin indicum, are a nutritious food, used as food as well as medicine in Vietnam.
  • Black sesame contains the compound Sesamin, a lignan, with an estrogen-like chemical formula that has anti-oxidant, anti-free radical, anti-inflammatory effects, inhibits vitamin E metabolism, and affects fat metabolism.

Uses of Nano Sesamin

1. Effects of reducing blood pressure

A small but statistically significant reduction in blood pressure may exist after the consumption of low doses of Sesamin in humans, which has been observed with the administration of Sesamin or sesame oil.

Clinical studies in women with mild hypertension, using 60 mg Sesamin for 4 weeks, recorded a significant reduction in systolic blood pressure (137.6 +/- 2.2 to 134.1 +/- 1, 7 mmHg; 2.6% decrease) and diastolic blood pressure (87.7 +/- 1.3 to 85.8 +/- 1.0 mmHg, 2.2% decrease).

2. Effects on fat metabolism

Research in rats shows that Sesamin inhibits the absorption of cholesterol from the intestines. But does not affect the absorption of unbound and unbound fatty acids and also does not affect bile acids.

Research in mice using 2% Sesamin in the diet (about 200mg/kg) prevented harmful genes in mouse liver after 15 days of use through fatty acid oxidation in the liver. These results suggest that Sesamin can be used as a fat burning supplement.

3. Effects on bone metabolism

In vitro cell culture research shows that Sesamin appears to promote bone cell growth and increase bone mass.

4. Anti-inflammatory effect

At a dose of 12mg/kg Sesamin administered via injection in mice is said to inhibit ERK1 factor and NF-kB activation in macrophages. Therefore, using high doses of Sesamin seems to have an effective anti-inflammatory effect, inhibiting factors that cause necrosis and inflammation.

5. Increase the effectiveness of vitamin E supplementation

Research on rats using a dose of 30mg/kg Sesamin has been recorded to increase the amount of vitamin E in the body by 50-55.8%. Inhibition of vitamin E decomposition after Sesamin supplementation through the following mechanism:

CYP3A participates in converting Vitamin E into carboxychroman metabolites, which is involved in vitamin E metabolism in the human body. Sesamin may reduce tocopherol metabolism via CYP3A (90% inhibition at 48h in isolated HepG2 cells).

6. Antioxidant effect

Sesamin’s antioxidant effects are due to its ability to scavenge harmful free radicals and reduce DNA damage caused by oxidation.

Research on mice that caused hepatotoxicity with Nickel, then supplemented the diet with Sesamin at 60-120mg/kg for 20 hours with Nickel showed that the group using Sesamin had a reduced increase in liver enzymes and less oxidative damage. through the 8-OHdG index.

7. Anti-cancer effects

In vitro studies demonstrate Sesamin’s anti-cancer effects. Sesamin prevents the proliferation of cancer-causing cell lines with a minimum concentration of 50% (IC50 – unit umol/L) of the following cell lines: KBM-5 leukemia cells (42.7), leukemia K562 (48.3), myeloma tumor266 (51.7), prostate tumor DU145 (60.2), colon tumor HTC116 (57.2), pancreatic tumor MiaPaCa-2 (58.3) , lung medullary adenocarcinoma H1299 (40.1), and breast cancer cells MDA-MB-231 (51.1).

In addition, Sesamin blocks TNF-a factor that causes cell proliferation and cancer-causing invasion genes in human endothelial cells.

8. Skin protective effect

Supplementation of 0.2% Sesamin to the diet for 6 weeks with vitamin E showed an effective skin protection effect against UVB ultraviolet rays, this effect is thought to increase vitamin E accumulation in the skin. skin, enhancing skin protection effectiveness.

Dosage: Oral dose of 100-150mg of sesamin per day, recommended to be used in full for its antioxidant effect, increasing the effectiveness of vitamin E supplementation.

Nano Sesamin is produced using modern Nano technology

Nano technology has overcome the weakness of Sesamin’s poor absorption ability by reducing Sesamin to a microscopic form with a size of 25-50 nm without completely changing the chemical structure and original biological nature. leading, providing products with high safety, outstanding efficiency and speed. This ultra-small size and new generation targeted packaging will help Nano Sesamin be completely soluble in water, increasing bioavailability hundreds of times compared to normal molecular size.

Sesamin Nano particle size result sheet measured by HR-Tem method

Microbiological result sheet of Nano Sesamin solution

Content result sheet of Nano Sesamin solution

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