Where does Gamma Oryzanol come from?

Gamma-oryzanol, a phytosterol derived from rice bran oil, is composed of a mixture of plant sterols esterified with phenol, particularly ferulic acid. Phytosterols play essential roles in plants, including growth, development, membrane fluidity, and antioxidant functions. Gamma-oryzanol was first isolated from rice bran oil by Japanese researchers Kaneko and Tsuchiya in the early 1950s and has since been used in Japan to treat anxiety, menopausal symptoms, stomach ulcers, and high blood lipids. Gamma-oryzanol is most abundantly found in rice bran oil, with a content of about 1% or 10mg/gram. It is also present in corn, barley, vegetable oils, rye, and wheat bran.

Gamma-oryzanol is not a substance, but a mixture of esters of ferulic acid with 10 triterpene alcohols: Delta⁷ – stigmastenyl ferulate, stigmasteryl ferulate, cycloartenyl ferulate, 24-methylenecycloartenyl ferulate, Delta⁷ – campestenylferulate, campesteryl ferulate, Delta⁷ – sitostenyl ferulate , sitosteryl ferulate, compestanyl ferulate and sitostanyl ferulate.
Cycloartenyl ferulate, 24-methylenecycloartanyl ferulate and campesteryl ferulate are the three main components of gamma-oryzanol. The basic structure of gamma-oryzanols is ferulic acid esterified to cyclopentanoperihydrophenanthrene.

Health Benefits

1. Reduce cholesterol in the blood
   Gamma oryzanol prevents cholesterol absorption by intestinal cells, its mechanism is to inhibit the enzyme HMG-CoA reductase (stain), an enzyme that promotes cholesterol production. Gamma-oryzanol inhibits the absorption of dietary cholesterol and also inhibits the reabsorption of endogenous cholesterol from the gastrointestinal tract. In addition, studies also show that using rice bran oil for 4 consecutive weeks will help reduce total cholesterol in plasma by about 6.3%, reduce LDL (bad cholesterol) by 10.5%, and reduce the rate of LDL/HDL (good HDL cholesterol) down to about 18.6%.
2. Prevent arteriosclerosis and atherosclerosis
   Studies show that enzymes in rice bran help reduce cholesterol and prevent the development of atherosclerotic plaque in mice with atherosclerosis and a high-fat diet. This compound reduces aortic fatty chains – visible damage in the process of arteriosclerosis. Arteriosclerosis or atherosclerosis is the main cause of heart disease, stroke, aneurysm, internal bleeding for patients with chronic diseases. Most of these diseases are dangerous because they pose a direct threat to life.
3. Gamma oryzanol is beneficial for diabetes
   Gamma oryzanol improves sugar levels by improving the function and survival of pancreatic beta cells (cells that release insulin). This compound directly acts on the pancreas to increase glucose-stimulating insulin production. In addition, it also enhances glucose absorption by fat cells, preventing the reduction of adiponectin (it is secreted by fat cells and acts as a hormone with anti-inflammatory effects and increases insulin sensitivity) in diabetics. Sugar. It should be noted that Gamma oryzanol does not directly produce insulin, but it acts to regulate autonomic nerves, improve the body’s immunity and improve the level of insulin in the body.
4. Gamma oryzanol is anti-inflammatory
   Some studies have shown that gamma oryzanol has anti-inflammatory properties by inhibiting the activity of the pro-inflammatory transcription factor NF – kappaB in macrophages. In mice gamma oryzanol reduced inflammatory mediators such as PGE2, TNF-alpha and LL-6. For humans, especially diabetics, the anti-inflammatory mechanism of gamma oryzanol is an effective solution to combat complications related to wound ulcers. Prevents ulcers and wounds that take longer to heal due to weakened immune system in diabetics.
5. Antioxidant and protects cells against oxidation reactions.
   Gamma oryzanol has been shown to have a variety of antioxidant activities by scavenging free radicals such as hydroxyl radical, superoxide anion radical and DPPH radical (2,2-diphenyl-I-picrylhydrazyl, a stable radical). In addition, it also inhibits lipid peroxidation caused by the azo compound AMVN (2,2′-azobis [2,4 dimethylvaleronitrile]). And it is also thought that the antioxidant activity of gamma-oryzanol may be due to mainly due to its metabolite, phenolic ferulic acid. Ferulic phenolic acid has strong antioxidant activity, due to the chemical properties of the phenolic hydroxyl group. In addition, ferulic acid has been shown to inhibit the expression or activity of cytotoxic enzymes, including nitric oxide synthase (iNOS), caspase and cyclooxygenase-2 (COX-2). According to studies, it has also been found that the antioxidant capacity of gamma oryzanol is 4 times higher than that of vitamin E. Recently, people often Use it in whitening cosmetics because it has the ability to slow down the progression of melanin pigmentation by preventing the impact of ultraviolet rays on the surface of the skin, limiting melasma, freckles, and dark spots.
6. Effects on the nervous system and premenopausal symptoms.
   Gamma oryzanol is effective in reducing symptoms of hot flashes, night sweats, and insomnia in premenopausal people. Furthermore, the combination of gamma-oryzanol and plant sterols has been used in the treatment of senile dementia, arteriosclerosis, and cerebellum. The mechanism of action of β-oryzanol is believed to be related to catecholamine metabolism in the hypothalamus.
7. Gamma oryzanol interaction with substances.
   Some active ingredients may interact with gamma-oryzanol such as: Ezetimibe can inhibit the absorption of gamma-oryzanol in the small intestine. Besides, gamma-oryzanol was found to have no inhibitory effect on gamma-oryzanol. Cytochrome P450 activities in human liver microsomes. This suggests that gamma-oryzanol will not cause clinically significant interactions with drugs that metabolize cytochrome P450. Not only that, combined use of the long-chain polyunsaturated acid DHA (docosahexaenoic acid), EPA (eicosapentaenoic acid) along with gamma oryzanol can create a synergistic effect in lowering blood lipids. With the great uses of gamma oryzanol, the compound is currently prepared and applied to drugs related to diabetes, support and treatment for diabetic patients to stabilize blood sugar, and reduce complications related to atherosclerosis such as high blood pressure, stroke and, most dangerous, cardiovascular complications.
   

Nano Gamma-oryzanol is produced using modern Nano technology

Nano technology has addressed the issue of poor absorption of Gamma-oryzanol by reducing it to a microscopic form with a size of 20-30 nm. This process preserves the chemical structure and biological nature of the original substance, ensuring high safety, exceptional effectiveness, and rapid action. The ultra-small size and new generation of targeted packaging enable Nano Gamma-oryzanol to be completely water-soluble, increasing bioavailability hundreds of times compared to its normal molecular size.

The process of formulating the Nano Gamma-oryzanol microemulsion system by OIC NEW

The process of formulating the Nano Gamma-oryzanol microemulsion by OIC NEW has been granted Utility Solution Patent No. 3630 by the Intellectual Property Office.

Nano Gamma-oryzanol material in liquid form is superior thanks to:

• Gamma-oryzanol raw material from high purity rice bran oil imported from Japan and auxiliary ingredients imported from the US and EU meet international pharmacopoeia standards.
• The size of medicinal medicinal particles is extremely small, below 30 nm.
• Gamma-oryzanol Nano particles are spherical, stable, and not destroyed by gastric acid. Microemulsion form completely dissolves in water, absorbing 99.9% into blood and cells.
• Exclusive PEG and PLA encapsulating membranes target the exact location of the injury.
• Nano Gamma-oryzanol is hundreds of times more effective than regular Gamma-oryzanol.

Packaging specifications and packaging materials

Packaging: 0.5 liters, 1 liter, 2 liters, 3 liters, 4 liters, 5 liters, 10 liters, 15 liters, 20 liters.
Close the glass jar or plastic container. Packaging meets quality standards used in food according to regulations of the Ministry of Health.
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For detailed information about ordering nano materials, please contact:
Nhat Hai New Technology Joint Stock Company – OIC NEW
No. 42, BT2, Linh Dam Peninsula, Hoang Liet Ward, Hoang Mai District, Hanoi.
Hotline: 1900 63 69 13